Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 12 Researches
7.5
USERS' SCORE
Good
Based on 3 Reviews
8.4
Supplement Facts
Serving Size: 2 Gummies
Serving Per Container: 30
Amount Per Serving
%DV
Calories
20
Total Carbohydrate
5 g
2%**
Total Sugars
3 g
†
Includes 3 g Added Sugars
6%**
Vitamin C
45 mg
50%
Zinc
7.5 mg
68%
Sodium
15 mg
<1%
Organic Black Elderberry Concentrate (Sambucus nigra) (fruit) (65:1)
150 mg
†
Organic VitaBerry® Fruit BlendStrawberry, Raspberry, Blueberry, Tart Cherry, Elderberry, Cranberry Powders
25 mg
†
Bacillus coagulans (Lactospore®)
10 mg(1 Billion CFU)
†
Top Medical Research Studies
7
We explored the relationship between serum zinc levels and chronic fatigue syndrome (CFS) in a study that compared patients with CFS to normal volunteers. By using an atomic absorption method, we measured serum zinc concentrations and found that those suffering from CFS had significantly lower levels of zinc compared to healthy individuals.
Interestingly, we observed a trend indicating that lower zinc levels correlated with greater CFS severity. Patients also reported a negative correlation between their zinc levels and their subjective experiences of infection. This suggests that zinc plays a role in the immune dysfunction commonly seen in CFS.
Furthermore, we noted that lower serum zinc was associated with higher levels of inflammatory markers and certain defects in the early activation of T cells. Since zinc acts as a potent antioxidant, our findings indicate that CFS is linked to increased oxidative stress in these patients. Given this, it may be beneficial for some CFS patients to consider zinc supplements as part of their treatment approach.
Interestingly, we observed a trend indicating that lower zinc levels correlated with greater CFS severity. Patients also reported a negative correlation between their zinc levels and their subjective experiences of infection. This suggests that zinc plays a role in the immune dysfunction commonly seen in CFS.
Furthermore, we noted that lower serum zinc was associated with higher levels of inflammatory markers and certain defects in the early activation of T cells. Since zinc acts as a potent antioxidant, our findings indicate that CFS is linked to increased oxidative stress in these patients. Given this, it may be beneficial for some CFS patients to consider zinc supplements as part of their treatment approach.
Read More
9
We evaluated the effects of zinc treatment on individuals with long COVID, focusing on how it relates to chronic fatigue syndrome. Our study involved 58 patients who underwent a unique therapy called Epipharyngeal Abrasive Therapy (EAT), which utilized zinc chloride as an anti-inflammatory agent for the epipharynx.
Participants were treated once a week for a month, and we measured the intensity of their symptoms, specifically fatigue, headaches, and attention disorders, using a visual analog scale (VAS). Remarkably, we found that EAT reduced inflammation in the epipharynx and resulted in significant improvements in the reported intensity of these symptoms.
We believe these findings highlight the potential role of zinc in managing symptoms associated with long COVID and possibly chronic fatigue syndrome. While the evidence is encouraging, it remains essential to conduct more in-depth research to truly understand the specific effects of zinc and ensure these benefits are consistently reproducible.
Participants were treated once a week for a month, and we measured the intensity of their symptoms, specifically fatigue, headaches, and attention disorders, using a visual analog scale (VAS). Remarkably, we found that EAT reduced inflammation in the epipharynx and resulted in significant improvements in the reported intensity of these symptoms.
We believe these findings highlight the potential role of zinc in managing symptoms associated with long COVID and possibly chronic fatigue syndrome. While the evidence is encouraging, it remains essential to conduct more in-depth research to truly understand the specific effects of zinc and ensure these benefits are consistently reproducible.
Read More
7
We examined how a combination of megadose vitamin C infusions and other treatments might help manage chronic fatigue syndrome, particularly in the context of interstitial pneumonia. Our findings were based on nearly a decade of treating patients, allowing us to gather valuable insights.
We observed that the long-term use of this treatment system significantly reduced the risk of pneumonia recurrence. It also appeared to help prevent the emergence of certain cancers in older patients suffering from interstitial pneumonia. Surprisingly, we found a link between interstitial pneumonia and an increased risk of depression, likely driven by prolonged glucocorticoid use.
While some patients showed promise under this treatment, those battling both interstitial pneumonia and depression responded less favorably. We suggested that increasing the amount of dehydroepiandrosterone in the treatment could be beneficial. Throughout our experience, we noted that the characteristics of chronic fatigue syndrome align closely with those of interstitial pneumonia, arguing against the notion that they should be viewed as separate conditions.
Overall, our approach not only alleviated inflammation but did not suppress the fibrotic processes in the long run. We made modifications to the treatment to lower the risks of vascular complications. The main strength of our treatment lies in creating a hormonal environment that helps tackle immune deficiencies using vitamin C, which faces lower resistance in the body compared to steroid treatments.
We observed that the long-term use of this treatment system significantly reduced the risk of pneumonia recurrence. It also appeared to help prevent the emergence of certain cancers in older patients suffering from interstitial pneumonia. Surprisingly, we found a link between interstitial pneumonia and an increased risk of depression, likely driven by prolonged glucocorticoid use.
While some patients showed promise under this treatment, those battling both interstitial pneumonia and depression responded less favorably. We suggested that increasing the amount of dehydroepiandrosterone in the treatment could be beneficial. Throughout our experience, we noted that the characteristics of chronic fatigue syndrome align closely with those of interstitial pneumonia, arguing against the notion that they should be viewed as separate conditions.
Overall, our approach not only alleviated inflammation but did not suppress the fibrotic processes in the long run. We made modifications to the treatment to lower the risks of vascular complications. The main strength of our treatment lies in creating a hormonal environment that helps tackle immune deficiencies using vitamin C, which faces lower resistance in the body compared to steroid treatments.
Read More
Most Useful Reviews
9
Increased energy levels
Good composition with fast delivery and quality packaging. I’ve taken one capsule daily for ten days and noticed significant benefits. My energy has increased, headaches have ceased, and I've experienced a boost in mood, effectively alleviating my chronic fatigue syndrome.
Read More
7.5
Improved cold symptoms
Excellent composition with a unique taste that lingers. I've found it effective in alleviating colds, hypothermia, and chronic fatigue syndrome.
Read More
7.5
Reduced fatigue symptoms
Outstanding product containing vitamin C and beneficial elderberry. The quality and ingredients are excellent, helping to combat chronic fatigue syndrome effectively.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 12 Researches
7.5
- All Researches
9
We investigated the effects of high dose intravenous vitamin C on patients suffering from chronic fatigue syndrome (CFS) linked to Epstein-Barr virus (EBV) infections. Our analysis included data from 178 patients who had elevated levels of EBV antibodies, alongside 40 who also showed signs of ongoing viral activity. Most of our participants were diagnosed with chronic fatigue syndrome, while others had related conditions such as mononucleosis or general fatigue.
What we found is quite promising. High doses of vitamin C appeared to reduce the duration of disease symptoms and helped decrease antibody levels associated with EBV. Notably, we observed that patients with higher levels of vitamin C in their plasma generally had lower levels of certain EBV antibodies, suggesting a potential link that might help manage symptoms of CFS.
Furthermore, there was an interesting connection between vitamin D levels and EBV antibodies as well. Patients who had high levels of vitamin D showed lower levels of EBV early antigen antibodies. This points towards a holistic approach to managing CFS, where both vitamin C and vitamin D may play beneficial roles. Overall, our findings hint at an encouraging effect of high dose vitamin C therapy in helping those grappling with CFS due to EBV.
What we found is quite promising. High doses of vitamin C appeared to reduce the duration of disease symptoms and helped decrease antibody levels associated with EBV. Notably, we observed that patients with higher levels of vitamin C in their plasma generally had lower levels of certain EBV antibodies, suggesting a potential link that might help manage symptoms of CFS.
Furthermore, there was an interesting connection between vitamin D levels and EBV antibodies as well. Patients who had high levels of vitamin D showed lower levels of EBV early antigen antibodies. This points towards a holistic approach to managing CFS, where both vitamin C and vitamin D may play beneficial roles. Overall, our findings hint at an encouraging effect of high dose vitamin C therapy in helping those grappling with CFS due to EBV.
Read More
9
We evaluated the effects of zinc treatment on individuals with long COVID, focusing on how it relates to chronic fatigue syndrome. Our study involved 58 patients who underwent a unique therapy called Epipharyngeal Abrasive Therapy (EAT), which utilized zinc chloride as an anti-inflammatory agent for the epipharynx.
Participants were treated once a week for a month, and we measured the intensity of their symptoms, specifically fatigue, headaches, and attention disorders, using a visual analog scale (VAS). Remarkably, we found that EAT reduced inflammation in the epipharynx and resulted in significant improvements in the reported intensity of these symptoms.
We believe these findings highlight the potential role of zinc in managing symptoms associated with long COVID and possibly chronic fatigue syndrome. While the evidence is encouraging, it remains essential to conduct more in-depth research to truly understand the specific effects of zinc and ensure these benefits are consistently reproducible.
Participants were treated once a week for a month, and we measured the intensity of their symptoms, specifically fatigue, headaches, and attention disorders, using a visual analog scale (VAS). Remarkably, we found that EAT reduced inflammation in the epipharynx and resulted in significant improvements in the reported intensity of these symptoms.
We believe these findings highlight the potential role of zinc in managing symptoms associated with long COVID and possibly chronic fatigue syndrome. While the evidence is encouraging, it remains essential to conduct more in-depth research to truly understand the specific effects of zinc and ensure these benefits are consistently reproducible.
Read More
8
Vitamin C may aid CFS management
We aimed to understand whether vitamin C infusion treatments could benefit those suffering from chronic fatigue syndrome (CFS). Specifically, we looked at two types of vitamin C infusion sets: one that included dehydroepiandrosterone (the new set) and one without it (the old set). Our investigation involved a male patient diagnosed with CFS, monitoring his health from August 1995 to May 1996.
Initially, the old infusion method, alongside some antibiotics, showed effectiveness in managing the patient’s pneumonia, which was a part of the CFS symptoms. However, over time, pneumonia symptoms returned, prompting us to alternate between the old and new vitamin C treatments along with longer antibiotic use. Remarkably, this switch led to a notable reduction in pneumonia signs.
We found that the new vitamin C infusion treatment dramatically increased urine excretion of certain hormones, suggesting an enhancement of the body’s steroid activities. Notably, some evidence indicated that the dehydroepiandrosterone was converted into testosterone, which could positively influence the CFS control. However, our searches for changes in immune response didn’t yield significant results.
Ultimately, our observations suggest that the new vitamin C treatment could help manage CFS by boosting cortisol and testosterone levels, but additional studies would be necessary to fully understand its effectiveness in isolation.
Initially, the old infusion method, alongside some antibiotics, showed effectiveness in managing the patient’s pneumonia, which was a part of the CFS symptoms. However, over time, pneumonia symptoms returned, prompting us to alternate between the old and new vitamin C treatments along with longer antibiotic use. Remarkably, this switch led to a notable reduction in pneumonia signs.
We found that the new vitamin C infusion treatment dramatically increased urine excretion of certain hormones, suggesting an enhancement of the body’s steroid activities. Notably, some evidence indicated that the dehydroepiandrosterone was converted into testosterone, which could positively influence the CFS control. However, our searches for changes in immune response didn’t yield significant results.
Ultimately, our observations suggest that the new vitamin C treatment could help manage CFS by boosting cortisol and testosterone levels, but additional studies would be necessary to fully understand its effectiveness in isolation.
Read More
We investigated the impact of a 3-month supplementation with a special synbiotic mixture on adults suffering from post-COVID-19 chronic fatigue syndrome (ME/CFS). This study was thoughtfully designed as a placebo-controlled, double-blind trial involving 26 participants. The intention was to see how this synbiotic, which notably contains zinc among other components, would influence patients' overall experiences, exercise tolerance, and metabolism in tissues affected by fatigue.
The promising findings indicated that taking the synbiotic mixture for three months improved metabolism and helped alleviate some clinical features associated with post-COVID fatigue syndrome. However, it's important to note that because zinc was part of this mixture, the study does not allow us to draw clear conclusions about zinc alone and its effects on chronic fatigue syndrome.
While our research shows that synbiotics may offer a safe and beneficial approach to managing symptoms of ME/CFS following COVID-19, further investigations are needed to fully understand the role of each component, including zinc, before making any strong recommendations for its use in this context.
The promising findings indicated that taking the synbiotic mixture for three months improved metabolism and helped alleviate some clinical features associated with post-COVID fatigue syndrome. However, it's important to note that because zinc was part of this mixture, the study does not allow us to draw clear conclusions about zinc alone and its effects on chronic fatigue syndrome.
While our research shows that synbiotics may offer a safe and beneficial approach to managing symptoms of ME/CFS following COVID-19, further investigations are needed to fully understand the role of each component, including zinc, before making any strong recommendations for its use in this context.
Read More
8
We conducted a clinical trial to examine how an oral food supplement (OFS) could impact patients suffering from long COVID, particularly focusing on inflammation and fatigue. This was a robust study design, featuring a double-blind, placebo-controlled setup that included 2 capsules of the supplement daily over two months.
The supplement contained a mix of ingredients like rosehip, propolis, royal jelly, zinc, and vitamin C. While zinc was part of the mix, we observed significant results in inflammation reduction through various parameters, such as a decrease in the neutrophil-to-lymphocyte ratio and C-reactive protein levels. However, we couldn’t isolate zinc's effects individually, as it was evaluated alongside other components.
Importantly, there were also noteworthy improvements in patients’ fatigue levels and overall quality of life, as measured by the fatigue severity scale. We found that vitamin D levels rose significantly in participants during the supplement phase, suggesting that the OFS has potential benefits beyond just zinc.
In conclusion, while this study reveals the OFS improved inflammatory symptoms, fatigue, and quality of life, we must recognize that we did not specifically analyze zinc's isolated effects on chronic fatigue syndrome.
The supplement contained a mix of ingredients like rosehip, propolis, royal jelly, zinc, and vitamin C. While zinc was part of the mix, we observed significant results in inflammation reduction through various parameters, such as a decrease in the neutrophil-to-lymphocyte ratio and C-reactive protein levels. However, we couldn’t isolate zinc's effects individually, as it was evaluated alongside other components.
Importantly, there were also noteworthy improvements in patients’ fatigue levels and overall quality of life, as measured by the fatigue severity scale. We found that vitamin D levels rose significantly in participants during the supplement phase, suggesting that the OFS has potential benefits beyond just zinc.
In conclusion, while this study reveals the OFS improved inflammatory symptoms, fatigue, and quality of life, we must recognize that we did not specifically analyze zinc's isolated effects on chronic fatigue syndrome.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
9
Increased energy levels
Good composition with fast delivery and quality packaging. I’ve taken one capsule daily for ten days and noticed significant benefits. My energy has increased, headaches have ceased, and I've experienced a boost in mood, effectively alleviating my chronic fatigue syndrome.
Read More
7.5
Improved cold symptoms
Excellent composition with a unique taste that lingers. I've found it effective in alleviating colds, hypothermia, and chronic fatigue syndrome.
Read More
7.5
Reduced fatigue symptoms
Outstanding product containing vitamin C and beneficial elderberry. The quality and ingredients are excellent, helping to combat chronic fatigue syndrome effectively.
Read More
Frequently Asked Questions
9
Increased energy levels
Good composition with fast delivery and quality packaging. I’ve taken one capsule daily for ten days and noticed significant benefits. My energy has increased, headaches have ceased, and I've experienced a boost in mood, effectively alleviating my chronic fatigue syndrome.
7.5
Improved cold symptoms
Excellent composition with a unique taste that lingers. I've found it effective in alleviating colds, hypothermia, and chronic fatigue syndrome.
7.5
Reduced fatigue symptoms
Outstanding product containing vitamin C and beneficial elderberry. The quality and ingredients are excellent, helping to combat chronic fatigue syndrome effectively.
9
We investigated the effects of high dose intravenous vitamin C on patients suffering from chronic fatigue syndrome (CFS) linked to Epstein-Barr virus (EBV) infections. Our analysis included data from 178 patients who had elevated levels of EBV antibodies, alongside 40 who also showed signs of ongoing viral activity. Most of our participants were diagnosed with chronic fatigue syndrome, while others had related conditions such as mononucleosis or general fatigue.
What we found is quite promising. High doses of vitamin C appeared to reduce the duration of disease symptoms and helped decrease antibody levels associated with EBV. Notably, we observed that patients with higher levels of vitamin C in their plasma generally had lower levels of certain EBV antibodies, suggesting a potential link that might help manage symptoms of CFS.
Furthermore, there was an interesting connection between vitamin D levels and EBV antibodies as well. Patients who had high levels of vitamin D showed lower levels of EBV early antigen antibodies. This points towards a holistic approach to managing CFS, where both vitamin C and vitamin D may play beneficial roles. Overall, our findings hint at an encouraging effect of high dose vitamin C therapy in helping those grappling with CFS due to EBV.
What we found is quite promising. High doses of vitamin C appeared to reduce the duration of disease symptoms and helped decrease antibody levels associated with EBV. Notably, we observed that patients with higher levels of vitamin C in their plasma generally had lower levels of certain EBV antibodies, suggesting a potential link that might help manage symptoms of CFS.
Furthermore, there was an interesting connection between vitamin D levels and EBV antibodies as well. Patients who had high levels of vitamin D showed lower levels of EBV early antigen antibodies. This points towards a holistic approach to managing CFS, where both vitamin C and vitamin D may play beneficial roles. Overall, our findings hint at an encouraging effect of high dose vitamin C therapy in helping those grappling with CFS due to EBV.
4
We explored the role of high-dose vitamin C infusions combined with dehydroepiandrosterone-cortisol in treating interstitial pneumonia, often linked with chronic fatigue syndrome. In a clinical setting since 1996, we've seen these treatments used for controlling symptoms and potentially improving outcomes in autoimmune disease management.
However, our findings highlight four key issues. First, it is still debated whether these treatments should continue on a maintenance basis when no acute symptoms are present. Some evidence suggests their ongoing use is crucial for halting an evolving bacterial colony in patients with immune deficiencies.
Second, we noted an emerging problem with drug-resistant bacteria, which posed challenges in treatment effectiveness. New antibiotics, like kanamycin, showed promise in addressing this resistance and improving pneumonia symptoms.
Third, we observed a decline in bone marrow function in one patient over a nine-year observation period, indicating potential fibrosis similar to that seen in lung tissue.
Lastly, we encountered a case where a female patient developed breast cancer during treatment, raising concerns about the risks of prolonged autoimmune conditions in older adults. Interestingly, dehydroepiandrosterone appeared to support hepatic recovery during cancer chemotherapy, suggesting complex interactions between treatments and patient responses.
Overall, while vitamin C plays a role in the treatment approach, the complexities of chronic fatigue syndrome and interstitial pneumonia present challenges that require further investigation.
However, our findings highlight four key issues. First, it is still debated whether these treatments should continue on a maintenance basis when no acute symptoms are present. Some evidence suggests their ongoing use is crucial for halting an evolving bacterial colony in patients with immune deficiencies.
Second, we noted an emerging problem with drug-resistant bacteria, which posed challenges in treatment effectiveness. New antibiotics, like kanamycin, showed promise in addressing this resistance and improving pneumonia symptoms.
Third, we observed a decline in bone marrow function in one patient over a nine-year observation period, indicating potential fibrosis similar to that seen in lung tissue.
Lastly, we encountered a case where a female patient developed breast cancer during treatment, raising concerns about the risks of prolonged autoimmune conditions in older adults. Interestingly, dehydroepiandrosterone appeared to support hepatic recovery during cancer chemotherapy, suggesting complex interactions between treatments and patient responses.
Overall, while vitamin C plays a role in the treatment approach, the complexities of chronic fatigue syndrome and interstitial pneumonia present challenges that require further investigation.
7
We examined how a combination of megadose vitamin C infusions and other treatments might help manage chronic fatigue syndrome, particularly in the context of interstitial pneumonia. Our findings were based on nearly a decade of treating patients, allowing us to gather valuable insights.
We observed that the long-term use of this treatment system significantly reduced the risk of pneumonia recurrence. It also appeared to help prevent the emergence of certain cancers in older patients suffering from interstitial pneumonia. Surprisingly, we found a link between interstitial pneumonia and an increased risk of depression, likely driven by prolonged glucocorticoid use.
While some patients showed promise under this treatment, those battling both interstitial pneumonia and depression responded less favorably. We suggested that increasing the amount of dehydroepiandrosterone in the treatment could be beneficial. Throughout our experience, we noted that the characteristics of chronic fatigue syndrome align closely with those of interstitial pneumonia, arguing against the notion that they should be viewed as separate conditions.
Overall, our approach not only alleviated inflammation but did not suppress the fibrotic processes in the long run. We made modifications to the treatment to lower the risks of vascular complications. The main strength of our treatment lies in creating a hormonal environment that helps tackle immune deficiencies using vitamin C, which faces lower resistance in the body compared to steroid treatments.
We observed that the long-term use of this treatment system significantly reduced the risk of pneumonia recurrence. It also appeared to help prevent the emergence of certain cancers in older patients suffering from interstitial pneumonia. Surprisingly, we found a link between interstitial pneumonia and an increased risk of depression, likely driven by prolonged glucocorticoid use.
While some patients showed promise under this treatment, those battling both interstitial pneumonia and depression responded less favorably. We suggested that increasing the amount of dehydroepiandrosterone in the treatment could be beneficial. Throughout our experience, we noted that the characteristics of chronic fatigue syndrome align closely with those of interstitial pneumonia, arguing against the notion that they should be viewed as separate conditions.
Overall, our approach not only alleviated inflammation but did not suppress the fibrotic processes in the long run. We made modifications to the treatment to lower the risks of vascular complications. The main strength of our treatment lies in creating a hormonal environment that helps tackle immune deficiencies using vitamin C, which faces lower resistance in the body compared to steroid treatments.
References
- Mikirova N, Hunninghake R. Effect of high dose vitamin C on Epstein-Barr viral infection. Med Sci Monit. 2014;20:725. doi:10.12659/MSM.890423
- Kodama M, Kodama T. Four problems with the clinical control of interstitial pneumonia, or chronic fatigue syndrome, using the megadose vitamin C infusion system with dehydroepiandrosterone-cortisol annex. In Vivo. 2006;20:285.
- Kodama M, Kodama T. The clinical course of interstitial pneumonia alias chronic fatigue syndrome under the control of megadose vitamin C infusion system with dehydroepiandrosterone-cortisol annex. Int J Mol Med. 2005;15:109.
- Kodama M, Kodama T, Murakami M. The value of the dehydroepiandrosterone-annexed vitamin C infusion treatment in the clinical control of chronic fatigue syndrome (CFS). II. Characterization of CFS patients with special reference to their response to a new vitamin C infusion treatment. In Vivo. 1996;10:585.
- Kodama M, Kodama T, Murakami M. The value of the dehydroepiandrosterone-annexed vitamin C infusion treatment in the clinical control of chronic fatigue syndrome (CFS). I. A Pilot study of the new vitamin C infusion treatment with a volunteer CFS patient. In Vivo. 1996;10:575.
- Ranisavljev M, Stajer V, Todorovic N, Ostojic J, Cvejic JH, et al. The effects of 3-month supplementation with synbiotic on patient-reported outcomes, exercise tolerance, and brain and muscle metabolism in adult patients with post-COVID-19 chronic fatigue syndrome (STOP-FATIGUE): a randomized Placebo-controlled clinical trial. Eur J Nutr. 2024;64:28. doi:10.1007/s00394-024-03546-0
- Noce A, Marrone G, Di Lauro M, Vita C, Montalto G, et al. Potential Anti-Inflammatory and Anti-Fatigue Effects of an Oral Food Supplement in Long COVID Patients. Pharmaceuticals (Basel). 2024;17. doi:10.3390/ph17040463
- Lacasa M, Alegre-Martin J, Sentañes RS, Varela-Sende L, Jurek J, et al. Yeast Beta-Glucan Supplementation with Multivitamins Attenuates Cognitive Impairments in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial. Nutrients. 2023;15. doi:10.3390/nu15214504
- Imai K, Yamano T, Nishi S, Nishi R, Nishi T, et al. Epipharyngeal Abrasive Therapy (EAT) Has Potential as a Novel Method for Long COVID Treatment. Viruses. 2022;14. doi:10.3390/v14050907
- Castro-Marrero J, Zaragozá MC, López-Vílchez I, Galmés JL, Cordobilla B, et al. Effect of Melatonin Plus Zinc Supplementation on Fatigue Perception in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial. Antioxidants (Basel). 2021;10. doi:10.3390/antiox10071010
- Maes M, Leunis JC. Normalization of leaky gut in chronic fatigue syndrome (CFS) is accompanied by a clinical improvement: effects of age, duration of illness and the translocation of LPS from gram-negative bacteria. Neuro Endocrinol Lett. 2008;29:902.
- Maes M, Mihaylova I, De Ruyter M. Lower serum zinc in Chronic Fatigue Syndrome (CFS): relationships to immune dysfunctions and relevance for the oxidative stress status in CFS. J Affect Disord. 2006;90:141.
